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目的和方法：应用免疫组织化学的方法对５０例膀胱移行细胞癌作ｐＲｂ、ｐ１６、ｐ５３和ＰＣＮＡ表达意义的研究。结果：ｐＲｂ、ｐ１６、ｐ５３和ＰＣＮＡ的阳性表达率分别是３０％、５８％、１４％及４４％。ｐＲｂ和ｐ１６的表达与肿瘤的病理分级呈负相关，而与肿瘤的临床分期无明显关系。ｐ５３和ＰＣＮＡ的表达与肿瘤的病理分级和临床分期均呈正相关。结论：ｐＲｂ、ｐ１６、ｐ５３和ＰＣＮＡ的异常表达在膀胱移行细胞癌的发生、发展过程中起重要的作用。ｐ５３和ＰＣＮＡ可作为判断其肿瘤的恶性程度和预后的重要指标。
PURPOSE AND METHODS: The expressions of pRb, p16, p53 and PCNA in 50 cases of bladder transitional cell carcinoma were studied by immunohistochemistry. Results: The positive rates of pRb, p16, p53 and PCNA were 30%, 58%, 14% and 44% respectively. The expression of pRb and p16 was negatively correlated with the pathological grade of the tumor, but not with the clinical stage of the tumor. The expression of p53 and PCNA was positively correlated with the pathological grade and clinical stage of the tumor. Conclusion: Abnormal expressions of pRb, p16, p53 and PCNA play an important role in the occurrence and development of bladder transitional cell carcinoma. p53 and PCNA can be used as an important indicator to determine the degree of malignancy and prognosis of their tumors.