目的:探讨超敏C-反应蛋白(hs-CRP)、肌钙蛋白I(cTnI)和心肌酶谱联合检测在儿科感染性疾病鉴别诊断中的意义。方法:应用全自动化学发光免疫分析仪和全自动生化分析仪对3组研究对象血清hs-CRP、cTnI、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)和α-羟丁酸脱氢酶(α-HBDH)分别进行测定,并做统计学处理。结果:hs-CRP在细菌感染组中(18.27±3.90)mg/L显著高于病毒组(5.56±0.60)mg/L和健康对照组(4.02±0.60)mg/L(P<0.05);cTnI在细菌组中(0.030±0.010)ng/ml显著低于病毒感染组(0.126±0.040)ng/ml(P<0.05),但高于健康对照组(0.022±0.010)ng/ml(P<0.05);CK、CK-MB、LDH和α-HBDH在细菌感染组中显著低于病毒感染组(P<0.05),但高于健康对照组(P<0.05)。结论:多项生化标志物联合检测综合判断,可弥补单项检测的不足,有利于感染性疾病患儿鉴别诊断,避免误诊而延误治疗。 Objective: To investigate the significance of combined detection of hs-CRP, cTnI and myocardial enzymes in the differential diagnosis of pediatric infectious diseases. Methods: Serum levels of hs-CRP, cTnI, creatine kinase (CK), creatine kinase MB (CK-MB), lactate dehydrogenation Enzyme (LDH) and α-hydroxybutyrate dehydrogenase (α-HBDH) were measured and statistically analyzed. Results: The hs-CRP levels in the bacterial infection group (18.27 ± 3.90) mg / L were significantly higher than those in the virus group (5.56 ± 0.60) mg / L and the healthy control group (4.02 ± 0.60) mg / L (0.030 ± 0.010) ng / ml in bacterial group was significantly lower than that in virus infected group (0.126 ± 0.040) ng / ml (P <0.05), but higher than that in healthy control group (0.022 ± 0.010) ng / ); CK, CK-MB, LDH and α-HBDH in the bacterial infection group were significantly lower than those in the viral infection group (P <0.05), but higher than those in the healthy control group (P <0.05). Conclusion: The combined judgment of multiple biochemical markers can make up for the deficiencies of single test, which is good for differential diagnosis of children with infectious diseases and avoid misdiagnosis and delay treatment.