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β-blockers have been recommended as a standardtreatment for patients with mild to moderate systolicchronic heart failure(CHF)because they not only relievepatients’symptoms but also decrease mortality.However,β-blockers have a variety of effects on different CHFpatients.Among them,β1-adrenergic receptor(AR)genepolymorphism is probably a significant one.The purposeof this study was to investigate the effects of metoprololon cardiac function,cardiac geometrical size and densityof β1-AR of CHF patients as well as the associationbetween two common single nucleotide polymorphisms(SNPs)of β1-AR(Gly389Arg and Ser49Gly)and theeffects of metoprolol.
β-blockers have been recommended as a standard treatment for patients with mild to moderate systolicchronic heart failure (CHF) because they not only relievepatients’symptoms but also decrease mortality. However, β-blockers have a variety of effects on different CHF patients. Amm them, β1-adrenergic receptor (AR) genepolymorphism is probably a significant one. The purpose of this study was to investigate the effects of metoprololon cardiac function, cardiac geometrical size and density of β1-AR of CHF patients as well as the associationbetween two common single nucleotide polymorphisms SNPs) of β1-AR (Gly389Arg and Ser49Gly) and the effects of metoprolol.