目的：合成新的联苯双酯类似物。方法：对联苯双酯的酯基进行结构修饰，合成了一些对称和不对称的联苯双酯类似物；用ＩＲ，１ＨＮＭＲ，ＭＳ和ＥＡ等进行结构鉴定。结果：完成了９个α联苯双酯酯基部分衍生物的合成，其中３个（３，４和５）为新化合物。结论：这些化合物大部分有较强的抗肿瘤活性。 Objective: To synthesize new bifendate analogues. Methods: The ester groups of bifendate were structurally modified and some symmetrical and asymmetrical bifendate analogues were synthesized. Their structures were elucidated by IR, 1HNMR, MS and EA. Results: The synthesis of nine α-bifendate ester derivatives was completed. Three of them (3, 4 and 5) were new compounds. Conclusion: Most of these compounds have strong anti-tumor activity.