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应用免疫组化ＡＢＣ法对５６例喉鳞癌和７例喉正常组织进行检测，探讨ＰＣＮＡ和ｐ２１的过度表达在喉癌发生、发展中的意义。结果在５６例喉癌中，ＰＣＮＡ和ｐ２１阳性率分别为７１．４％和７３．２％。正常组织染色均阴性。喉癌的临床分期、有无淋巴结转移和患者术后３年生存率与ＰＣＮＡ阳性率关系密切，与ｐ２１阳性表达无明显关系。提示检测ＰＣＮＡ有助于评估喉癌的预后，ｐ２１对判断喉癌的预后无明显价值
Fifty-six cases of laryngeal squamous cell carcinoma and seven cases of laryngeal squamous cell carcinoma were examined by immunohistochemical ABC method to explore the significance of overexpression of PCNA and p21 in the occurrence and development of laryngeal cancer. Results In 56 cases of laryngeal carcinoma, the positive rates of PCNA and p21 were 71.4% and 73.2% respectively. Normal tissue staining were negative. The clinical stage of laryngeal cancer, with or without lymph node metastasis and postoperative 3-year survival rate was closely related to the positive rate of PCNA, and no significant relationship with p21 positive expression. Prompt detection of PCNA helps to assess the prognosis of laryngeal cancer, p21 to judge the prognosis of laryngeal cancer no significant value