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目的:观察滋水清肝饮联合小剂量奥曲肽治疗肝硬化腹水的疗效及对肾脏血流动力学的影响。方法:将本院肝病科收治符合纳入标准的60例肝硬化腹水患者,随机分为治疗组与对照组,每组各30例,对照组采用常规治疗并予以小剂量奥曲肽注射液治疗;治疗组在对照组治疗基础上联合滋水清肝饮治疗,连续治疗8周后观察两组临床疗效、肝功能指标(ALT、AST、ALB、TBIL)及肾脏血流动力学(双侧肾动脉内经D、平均血流速度V、血流阻力指数RI)等指标变化。结果:疗程结束后,治疗组临床总有效率(86.7%)明显高于对照组(70.0%),组间比较,差异有统计学意义(P<0.05);两组患者肝功能较治疗前均有改善,然治疗组改善更显著,且治疗组肾脏血流指标D、V、RI与对照组比较,差异有统计学意义(P<0.05)。结论:滋水清肝饮联合小剂量奥曲肽治疗肝硬化腹水患者临床疗效确切,可有效改善患者肾脏血流动力学及肝功能指标。
Objective: To observe the therapeutic effect of Zishui Qinggan Decoction combined with low-dose octreotide on cirrhosis ascites and its effect on renal hemodynamics. Methods: Sixty patients with liver cirrhosis who met the inclusion criteria were randomly divided into treatment group and control group, with 30 cases in each group. The control group was treated with conventional therapy and treated with low dose of octreotide injection. The treatment group On the basis of the control group, combined with nourishing qi and qinggan yin therapy, the curative effect, liver function indexes (ALT, AST, ALB, TBIL) and renal hemodynamics (bilateral renal artery via D , The average blood flow velocity V, blood flow resistance index RI) and other indicators change. Results: At the end of treatment, the total effective rate (86.7%) in the treatment group was significantly higher than that in the control group (70.0%). There was significant difference between the two groups (P <0.05) Improve, but the treatment group improved more significantly, and the treatment group renal blood flow index D, V, RI compared with the control group, the difference was statistically significant (P <0.05). Conclusion: The clinical curative effect of Zishui Qinggan Decoction combined with low-dose octreotide in patients with cirrhosis and ascites is accurate, which can effectively improve the renal hemodynamics and liver function indexes.