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目的观察蛋白激酶抑制剂(盐酸法舒地尔)治疗急性缺血性脑卒中的临床疗效。方法选择2006年10月至2007年8月于云南省大理市第二人民医院就诊、发病在48 h 以内的急性缺血性脑卒中患者36例,与入院治疗时间相同、使用双氢吡啶类钙拮抗剂(尼莫地平)治疗的急性缺血性脑卒中患者36例进行比较。结果盐酸法舒地尔可显著提高急性缺血性脑卒中患者偏瘫肢体肌力,明显缩短肢体肌力恢复时间,降低患者的致残率。结论盐酸法舒地尔是治疗急性缺血性脑卒中较为安全有效的药物。
Objective To observe the clinical efficacy of protein kinase inhibitor (fasudil hydrochloride) in the treatment of acute ischemic stroke. Methods Thirty-six patients with acute ischemic stroke who were diagnosed within 48 hours in the Second People’s Hospital of Dali, Yunnan Province from October 2006 to August 2007 were treated with dihydropyridine calcium Antagonists (nimodipine) treatment of acute ischemic stroke in 36 patients were compared. Results Fasudil hydrochloride could significantly improve the muscle strength of hemiparetic limbs in patients with acute ischemic stroke, significantly shorten the recovery time of limb muscle strength and reduce the morbidity of patients. Conclusion Fasudil hydrochloride is a safe and effective drug in the treatment of acute ischemic stroke.