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目的观察口服蒿甲醚控制日本血吸虫病重疫区人群感染及预防急性感染的效果。方法在鄱阳湖区血吸虫病易感季节(5~10月)对重疫区村居民采用15d间隔口服蒿甲醚预防感染。同时设对照组,口服安慰剂。结果感染季节结束后,实验组人群粪检阳性率为0.83%,无急性感染发生;对照组粪检阳性率为15.01%,发生3例急性感染。结论每15天间隔口服蒿甲醚1次,对重疫区人群有良好的保护作用,保护率为94.47%,有利于控制人群感染;对防止急性感染也有明显效果。
Objective To observe the effect of oral administration of artemether on the control of human infection and prevention of acute infection in severe epidemic area of schistosomiasis japonica. Methods In the Poyang Lake area schistosomiasis susceptible season (May-October) residents of the epidemic-prone area 15d intermittent oral administration of artemether to prevent infection. At the same time set the control group, oral placebo. Results At the end of the infection season, the positive rate of fecal examination in the experimental group was 0.83%, no acute infection occurred. In the control group, the positive rate of fecal examination was 15.01%, and 3 cases of acute infection occurred. Conclusions Oral administration of artemether once every 15 days interval has a good protective effect on the population in the heavy epidemic area with the protection rate of 94.47%, which is beneficial to control the crowd infection and has obvious effect on preventing acute infection.