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本文采用ELISA方法测定103例乙型肝炎患者在病程不同时期血清中肝刺激物质（Hepatic，stimulatorsubstance，HSS）含量，与42例正常对照及其HBVDNA比较。结果：乙型肝炎患者血清HSS含量显著高于正常对照组（P＜0．01）；HBVDNA阳性组患者的血清HSS水平高于HBVDNA阴性组（P＜0．05）。上述结果说明：乙型肝炎患者血清HSS含量升高，HBV复制活跃可能是血清HSS水平升高的机制之一。
In this paper, the serum levels of Hepatic stimulator substance (HSS) in 103 patients with hepatitis B were measured by ELISA, compared with 42 normal controls and their HBVDNA. Results: The serum levels of HSS in patients with hepatitis B were significantly higher than those in normal controls (P <0.01). The serum levels of HSS in HBVDNA-positive patients were higher than those in patients with negative HBVDNA (P <0.05). The above results show that: hepatitis B patients with elevated serum HSS levels, HBV replication may be one of the mechanisms of serum HSS levels.