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目的:观察槟榔碱对HUVECs表型的诱导作用。方法:采用免疫细胞化学法检测HUVECs中α-SMA的表达情况。结果:经5～80μg/mL浓度槟榔碱处理10 d,HUVECs表达α-SMA(P﹤0.05)。结论:槟榔碱干预HUVECs可诱导细胞发生EndMT,提示这种转分化机制可能涉及到OSF的发生发展过程。
Objective: To observe the effect of arecoline on the phenotype of HUVECs. Methods: Immunocytochemistry was used to detect the expression of α-SMA in HUVECs. Results: α-SMA was expressed in HUVECs after being treated with arecoline at concentration of 5 ~ 80μg / mL for 10 days (P <0.05). CONCLUSION: Arecoline can induce EndMT in HUVECs, suggesting that this mechanism of transdifferentiation may involve the development and progression of OSF.