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20例柯兴综合征者血浆心钠素(ANP)均值为782±67pg/ml,明显高于正常对照组(339±34pg/ml),手术治疗后,血浆ANP随血、尿皮质醇(F)、血压下降而降至436±49pg/ml,相关检验示:血浆ANP与收缩压、舒张压及血、尿皮质醇均呈正相关;提示:柯兴综合征者血浆ANP升高可能与过度分泌的肾上腺皮质激素导致血容量增加、血压升高有关,柯兴综合征者血浆ANP升高可能是其病理生理过程中有益的代偿性反应。
The plasma atrial natriuretic factor (ANP) in 20 patients with Cushing’s syndrome was 782 ± 67pg / ml, which was significantly higher than that of the control group (339 ± 34pg / ml). After the operation, ), Blood pressure dropped to 436 ± 49pg / ml, the relevant tests show: plasma ANP and systolic blood pressure, diastolic blood pressure and urine were positively correlated with cortisol; Tip: Cushing syndrome plasma ANP may be associated with excessive secretion Of adrenal cortex hormones lead to increased blood volume, blood pressure, Cushing’s syndrome plasma ANP may be beneficial in the pathophysiology of compensatory response.