Stroke is the second leading cause of death worldwide with about 50％ of survivors being chronically disabled (Donkor, 2018). The behavioral improvement seen in stroke patients in the first weeks after a stroke is contributed by behavioral compensation, reorganization in somatotopic maps and activity in peri-infarct but also distant regions which are connected to the stroke area as supported by animal studies. Spontaneous recovery is related to region-specific changes in recovery-related genes (Ito et al., 2018), growth factor expression, axonal sprouting and dendritic spine turnover (Murphy and Corbett, 2009).