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目的 观察化疗加放疗对乳腺癌脑转移的疗效。方法 92例经CT、MRT确诊乳腺癌脑转移的病例 ,随机分成治疗组 (放疗加化疗 )和对照组 (单纯放疗 ) ,各 4 6例。对照组治疗方案为DT 4 0Gy 4周 ,部分单发病灶增加 10 -2 0Gy 1- 2周 ,治疗组 4 6例在对照组的基础上加用“CAF”方案化疗。结果 对照组 1年和 2年生存率分别为 15 .2 %和6 .5 % ,治疗组则分别为 4 5 .6 %和 19.5 %。两组一年生存率有显著差异性 (P <0 .0 5 ) ,2年生存率无显著差异性。两组患者不良反应无显著性差异性 (P >0 .0 5 )。脑单发病灶和多发病灶患者的 2年生存率为 2 9%和 3.4 % ,具显著差异性(P <0 .0 5 )。结论 放疗加化疗综合治疗对乳腺癌脑转移有较好疗效 ,且能耐受 ,对脑部单发转移疗效好于多发转移。
Objective To observe the effect of chemotherapy and radiotherapy on brain metastases of breast cancer. Methods Ninety-two cases of brain metastases from breast cancer were diagnosed by CT and MRT and were randomly divided into treatment group (radiotherapy plus chemotherapy) and control group (radiotherapy alone), 46 cases in each. Control group for the treatment of DT 4 0Gy 4 weeks, some single lesions increased 10 -2 0Gy 1 - 2 weeks, 46 cases in the treatment group in the control group based on the addition of “CAF” regimen chemotherapy. Results The 1-year and 2-year survival rates in the control group were 15.2% and 6.5%, respectively, and those in the treatment group were 45.6% and 19.5%, respectively. There was a significant difference in one-year survival rates between the two groups (P <0.05). There was no significant difference in 2-year survival rates between the two groups. Adverse reactions between the two groups showed no significant difference (P> 0.05). The 2-year survival rates of patients with single brain lesion and multiple focal lesions were 29% and 3.4%, respectively, with significant differences (P <0.05). Conclusion Radiotherapy and chemotherapy combined therapy has a good effect on brain metastases of breast cancer, and can tolerate, the single brain metastasis better than multiple metastases.