目的:探讨肿瘤相关巨噬细胞(TAM)及血管内皮生长因子(VECF)在外周T细胞淋巴瘤非特指型(PTCL-NOS)中的表达及临床意义。方法:采用免疫组织化学方法对60例PTCL-NOS患者肿瘤组织中的CD68和VEGF进行检测,15例正常人淋巴结组织为对照。结果:肿瘤组织中CD68阳性细胞平均含量为(56.5±18.6)个/高倍镜视野,而对照组为(12.4±6.2)个/高倍镜视野(P<0.01),肿瘤组织与对照组VEGF阳性表达率分别为78.3%和26.7%(P<0.05)。TAM与骨髓侵犯、IPI评分及疗效相关(P<0.05)。TAM高表达组和低表达组的2年总生存率(overall survival,OS)分别为23.6%和55.3%(P<0.05)。VEGF的表达与肿瘤分期、骨髓侵犯和IPI评分相关(P<0.05),VEGF表达阳性组和阴性组的2年OS分别为22.9%和83.3%(P<0.01)。单变量生存分析显示VEGF表达、TAM计数、肿瘤分期、IPI评分和疗效是独立的预后影响因素(P<0.05)。多变量分析显示VEGF和疗效是独立的预后影响因素(P<0.05)。结论:TAM和VEGF在PTCL-NOS中表达明显升高,单因素分析显示二者是PTCL-NOS的不良预后因素。多因素分析显示仅VEGF是独立的预后影响因素。 Objective: To investigate the expression and clinical significance of tumor-associated macrophages (TAM) and vascular endothelial growth factor (VECF) in peripheral T-cell lymphoma (PTCL-NOS). Methods: Immunohistochemistry was used to detect CD68 and VEGF in 60 cases of PTCL-NOS tumor tissues and 15 cases of normal human lymph node tissue as control. Results: The average content of CD68 positive cells in the tumor tissue was (56.5 ± 18.6) / high magnification, compared with (12.4 ± 6.2) / high magnification in the control group (P <0.01). The positive expression of VEGF in the tumor tissue and the control group Rates were 78.3% and 26.7%, respectively (P <0.05). TAM was associated with bone marrow invasion, IPI score and efficacy (P <0.05). The 2-year overall survival (OS) of TAM high expression group and low expression group were 23.6% and 55.3%, respectively (P <0.05). The expression of VEGF was correlated with tumor stage, bone marrow invasion and IPI score (P <0.05). The 2-year OS was 22.9% and 83.3% respectively in VEGF-positive group and negative group (P <0.01). Univariate survival analysis showed that VEGF expression, TAM count, tumor stage, IPI score and efficacy were independent prognostic factors (P <0.05). Multivariate analysis showed that VEGF and efficacy were independent prognostic factors (P <0.05). Conclusion: The expression of TAM and VEGF in PTCL-NOS significantly increased, univariate analysis showed that both are poor prognostic factors of PTCL-NOS. Multivariate analysis showed that VEGF alone was an independent prognostic factor.