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目的:探讨舒利迭联合孟鲁司特(montelukast)治疗重度哮喘的临床疗效。方法:收治重度哮喘患者88例,随机分成对照组和观察组各44例,对照组予舒利迭1吸/次,早晚各1次/日。观察组在对照组的基础上孟鲁司特咀嚼片,3～6岁4mg,6～12岁5mg,>12岁10mg,均每晚顿服,疗程3个月。结果:两组经过治疗,对照组显效12例,显效率27.3%,有效14例,有效率31.8%,无效26例,总有效率59.1%,复发9例,复发率20.5%;观察组显效20例,显效率45.5%,有效19例,显效率43.2%,无效5例,总有效率88.6%,复发3例,复发率6.8%,两组比较差异有显著性(P<0.05),两组经过治疗肝功能、肾功能和血常规、尿常规均无异常,观察组有1例出现呕吐,改为饭后服用后,症状消失。结论:舒利迭联合孟鲁司特(montelukast)治疗重度哮喘疗效确切,不良反应少,复发率低。
Objective: To investigate the clinical efficacy of seretide in combination with montelukast in the treatment of severe asthma. Methods: A total of 88 patients with severe asthma were randomly divided into control group and observation group, 44 cases in each group. The control group was treated with sulpiride 1 times a day, morning and evening, once a day. The observation group on the basis of the control group, montelukast chewable tablets, 3 to 6 years old 4mg, 6 to 12 years old 5mg,> 12 years old 10mg, served Dayton every night, treatment for 3 months. Results: The two groups were treated, the control group markedly effective in 12 cases, markedly effective rate of 27.3%, effective in 14 cases, effective rate was 31.8%, 26 cases were ineffective, the total effective rate was 59.1%, 9 cases of recurrence, the recurrence rate was 20.5%; The effective rate was 45.5%, effective rate was 19, effective rate was 43.2%, invalid rate was 5, total effective rate was 88.6%, relapse was 3, recurrence rate was 6.8%, there was significant difference between the two groups (P <0.05) After treatment of liver function, renal function and blood, urine routine no abnormalities, observation group, 1 case of vomiting, changed to after meals, the symptoms disappear. Conclusion: The combination of seretide and montelukast in patients with severe asthma is effective, with few adverse reactions and low recurrence rate.