论文部分内容阅读
目的:了解1,3-β-D葡聚糖在早产儿真菌感染诊断中的意义。方法:选用广东省第二人民医院2012年1~12月NICU住院的早产儿35例作为观察组,选用真菌药物治疗动态检测1,3-β-D葡聚糖,评价其对抗真菌药物疗效的价值。结果:观察组患者治疗前血浆中1,3-β-D葡聚糖含量为(302.1±103.5)pg/ml,对照组为(165.2±104.3)pg/ml,差异有统计学意义(t=2.21,P<0.01)。7天治疗后含量差异无统计学意义(P>0.05);界值为15 pg/ml时,敏感性与特异性之和最大,即诊断的误诊率与漏诊率之和最小,说明本研究结果 15 pg/ml为最佳阳性界值。结论:项目的研究不仅可以让深部真菌感染的患儿得到及早治疗,降低病死率,还可以节省大量医疗资源,减轻患儿未发育成熟的器官组织的负荷及患儿家长的经济负担,避免抗真菌药物的过度使用,减少耐药菌株的产生。
Objective: To investigate the significance of 1,3-β-D-glucan in the diagnosis of fungal infection in premature infants. Methods: 35 cases of premature infants who were hospitalized in NICU from January to December 2012 in Guangdong Second People’s Hospital were selected as the observation group. The fungal drugs were used to detect 1,3-β-D-glucan dynamically to evaluate the antifungal efficacy value. Results: The plasma 1,3-β-D-glucan level in the observation group before treatment was (302.1 ± 103.5) pg / ml and in the control group was (165.2 ± 104.3) pg / ml, the difference was statistically significant (t = 2.21, P <0.01). There was no significant difference in the content after 7 days of treatment (P> 0.05). When the cutoff value was 15 pg / ml, the sum of the sensitivity and specificity was the largest, that is, the sum of misdiagnosis rate and missed diagnosis rate was the smallest. 15 pg / ml as the best positive cutoff. Conclusion: The study not only can make early fungal infection in children with early treatment, reduce mortality, but also can save a lot of medical resources, reduce the burden on children’s immature organ tissue and the economic burden of parents, to avoid Overuse of fungal drugs reduces the production of resistant strains.