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目的分析实性假乳头状肿瘤(SPT)伴肝转移的临床病理特点,提高对该病的认识。方法对1例肝穿刺标本诊断实性假乳头状肿瘤的临床资料、镜下观察及免疫组化结果进行分析。结果组织学:肿瘤有实性区、囊性区及假乳头区,假乳头区肿瘤细胞围绕血管周围排列,以纤细的纤维血管为轴心形成假乳头结构。肿瘤细胞中等大小,较一致,胞质嗜酸或空泡状,细胞核圆形、卵圆形,可见核沟,有轻度异型性。免疫组化:α1-AT、α1-ACT、CD56、Syn、CD10β-catenin和cyclin D1(+),hepatocyte和E-cadherin(-)。结论肝穿刺标本可以诊断少见的转移性SPT,免疫组化检测对诊断具有重要意义。
Objective To analyze the clinicopathological features of solid pseudopapillary tumor (SPT) with liver metastasis and to improve the understanding of the disease. Methods The clinical data, microscopic observation and immunohistochemistry results of one case of liver puncture specimen diagnosed with solid pseudopapillary tumor were analyzed. Results Histology: solid tumor area, cystic area and pseudopapillary area, pseudopapillary tumor cells arranged around the blood vessels around the slender fibrovascular axis to form a pseudopapillary structure. Tumor cells of medium size, more consistent, cytoplasmic acidophilic or vacuolar, round nucleus, oval, visible nuclear ditch, with mild atypia. Immunohistochemistry: α1-AT, α1-ACT, CD56, Syn, CD10β-catenin and cyclin D1 (+), hepatocyte and E-cadherin (-). Conclusions Hepatic puncture can diagnose rare metastatic SPT. Immunohistochemical detection is of great significance in diagnosis.