骨髓和外周血中新形成的嗜多染红细胞中的微核,常用作红母细胞期发生染色体损伤的一项指标。过去认为这种畸变的细胞在外周循环中很快被清除,将这些畸变细胞的出现率用检于测以低剂量染毒的亚慢性或慢性毒性试验中出现的染色体损伤是不合适的。最近在小鼠中发现,在外周血中,有微核的红细胞并没有被选择性地清除,提示外周血中成熟(正染)红细胞的微核发生率可作为这种动物慢性染色体断裂的一项有用的指标。本文报告六种遗传 Micronuclei in the newly formed polychromatic erythrocytes in bone marrow and peripheral blood are often used as an indicator of chromosomal damage at the red cell stage. Cells that were previously thought to be aberrant were quickly cleared in the peripheral circulation and the presence of these aberrant cells was inappropriately tested for chromosomal damage that occurred in subchronic or chronic toxicity tests that tested at low doses. It has been recently found in mice that erythrocytes with micronuclei have not been selectively cleared in peripheral blood, suggesting that the incidence of micronuclei of mature (positively-stained) erythrocytes in peripheral blood may serve as one of the chronic chromosomal breaks in this animal Useful indicators. This article reports six genetics