疱疹性角膜炎是眼科临床上常见的眼病,因本病对视力危害较大,往往造成斑翳而严重影响视力。此种角膜炎可发生于任何年龄,一般为单眼受累,但也有少数双眼同时发病或先后发病者。侵犯角膜实质层病例,其病程往往较长,有时可长达数月,且易于复发。目前抗病毒药物如疱疹净(IDU)、环胞苷(CC)、阿糖胞苷(Ara-C)、阿糖腺苷(Ara-A)、亚磷酰乙酸(PAA)等药物的广泛应用,虽然对本病有一定的疗效,但常常可产生耐药性而降低疗效,甚至不能控制病变的发展,且难以防止复发。另外上述抗病毒药物对角膜有一定毒性反应。近年来我院采用人白细胞干扰素与上述抗病毒药联合应用,不仅大大缩短病程,且复发率也大大降低。现将我院临床应用情况报告如下。 Herpes keratitis is a common eye disease in clinical ophthalmology, because of the greater risk of visual acuity, often cause canthus and seriously affect vision. Such keratitis can occur at any age, usually unilateral involvement, but also a small number of simultaneous onset of both eyes or who. Cases of violations of the corneal parenchyma, the course is often longer, sometimes up to several months, and easy to relapse. The wide range of applications of current antiviral drugs such as herpes simplex (IDU), cytidine (CC), Ara-C, Ara-A and phosphoacetate (PAA) , Although the disease has a certain effect, but often can produce drug resistance and reduce the efficacy, and even can not control the development of the disease, and it is difficult to prevent recurrence. In addition the antiviral drugs on the cornea has a certain toxicity. In recent years, our hospital using human leukocyte interferon combined with the above antiviral drugs, not only greatly shorten the course of disease, and the recurrence rate is greatly reduced. Now our hospital clinical application is as follows.