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患者女,48岁.全身多发性丘疹、结节近2年,双手、双膝关节僵硬,变形1余年.皮损组织病理示:镜下见真皮及皮下结节状病灶,由组织细胞和多核巨细胞组成,胞质嗜酸性,呈“毛玻璃”样.抗酸染色(-),免疫组化染色示上述组织细胞为CD68(+),s-100(-).诊断:多中心网状组织细胞增生症.治疗:口服甲波尼龙40mg1次/d,环磷酰胺0.1g 1 次/d等,并逐级减量.治疗2个月后,病情明显好转.“,”A 48-year-old female presented with papules,nodules for less than 2 years,and limitation and deformity of the fingers and knees last for more than 1 year.Histopathological finding showed multinucleated giant cells with eosinophilic cytoplasm which was in appearance of ground glass in dermis.Immunohistochemical staining showed that the histiocytes and multinucleated giant cells were CD68 positive,S-100 negative.The diagnosis was multicentric reticulorhistiocytosis.The patient got improvement with methylprednisolone 40 mg qd and cyclophosphamide 0.1 qd etc.,and the dosage was reduced gradually.After 2 months treatment,the patients had improved significantly.