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目的研究急性脑梗塞患者及健康人红细胞膜脂质含量、红细胞膜流动性及红细胞变形性。方法采用Ｌｏｗｒｙ法进行红细胞膜蛋白定量，Ｐａｒｅｋｈ法测定膜胆固醇，Ｌｉｎｄｂｅｒｇ法测定膜磷脂，Ａｏｚａｋｉ法测定红细胞膜流动性，ＢＬ８８－Ｃ激光衍射仪测定红细胞变形性。结果急性脑梗塞患者红细胞膜胆固醇增高，膜胆固醇与膜磷脂之比上升，膜流动性减低，红细胞变形性下降。结论膜成分的异常影响膜功能是脑梗塞发病的重要病理基础，临床上积极对血液成分进行调控，对预防和治疗脑梗塞有一定的实际意义。
Objective To study the lipid content, erythrocyte membrane fluidity and erythrocyte deformability of erythrocyte membrane in patients with acute cerebral infarction and healthy people. Methods The erythrocyte membrane protein was quantified by Lowry method. Membrane cholesterol was determined by Parekh method. Membrane phospholipid was determined by Lindberg method. The erythrocyte membrane fluidity was determined by Aozaki method. The erythrocyte deformability was determined by BL88-C laser diffractometer. Results In patients with acute cerebral infarction, erythrocyte membrane cholesterol increased, the ratio of membrane cholesterol to membrane phospholipid increased, membrane fluidity decreased and erythrocyte deformability decreased. Conclusion Membrane dysfunction is an important pathological basis for the pathogenesis of cerebral infarction. Active regulation of blood components in clinical practice has certain practical significance in the prevention and treatment of cerebral infarction.