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目的:研究前列腺素E1以及腺苷对离体兔肺的保护作用。方法:将18只新西兰大白兔分为3个实验组,分别为单纯UW液(A组、对照组)、UW液+前列腺素E1(B组)、UW液+腺苷(C组)。切取实验兔整体心肺作为离体心肺模型,对心肺模型进行冷灌注、低温保存。分别在2h末和4h末,取肺部分标本做电镜分析。于4h末,结扎右肺门,取右肺检测肺湿/干重比(W/D)、测肺气道压力(Paw)。左侧离体心肺接呼吸机模拟移植手术后呼吸,并将自身静脉血用泵从主肺动脉泵入,用负压吸引真空试管取左心房血液做血气分析。结果:B组肺组织气体交换功能的保护作用以及降低供体肺保存过程中含水量的作用明显优于其他组;降低气道压力和C组相当,明显优于对照组。C组肺实质细胞的气体交换功能的保护、降低肺含水量以及降低气道压力明显优于A组。结论:UW液中加入前列腺素E1进行离体肺灌注可以使肺保存时间明显延长、肺气体交换功能保存良好。
Objective: To study the protective effect of prostaglandin E1 and adenosine on isolated rabbit lung. Methods: Eighteen New Zealand white rabbits were divided into three groups: UW solution (group A, control group), UW solution + prostaglandin E1 (group B) and UW solution + adenosine group (C). The whole heart and lung of the experimental rabbits were cut out as a model of isolated cardiopulmonary and cold-perfusion of the model of cardiopulmonary and cryopreservation. At the end of 2h and end of 4h respectively, some lung specimens were taken for electron microscopic analysis. At the end of 4h, the right hilum was ligated and the right lung was taken to measure the wet / dry weight ratio (W / D). The pulmonary airway pressure (Paw) was measured. The left side of the heart-lung ventilator to simulate the respiration after transplantation, and pump their own venous blood pump from the main pulmonary artery, vacuum tube with a vacuum to take the left atrium to do blood gas analysis. Results: The protective effect of gas exchange function in lung tissue of group B and the effect of reducing the water content during donor lung preservation were significantly better than those in other groups. The reduction of airway pressure was equivalent to that of group C, which was significantly better than that of control group. C group of lung parenchymal cells gas exchange protection, reduce lung water content and reduce airway pressure was significantly better than the A group. Conclusion: Ex vivo pulmonary perfusion with UW fluid by adding prostaglandin E1 can significantly prolong the preservation time of the lungs and preserve the lung gas exchange function.