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目的 :探讨 (Dubin Johnsonsyndrome ,DJS)的诊断和鉴别方法。 方法 :对北京医科大学第三医院 196 0～1998年确诊的 10例DJS进行回顾性分析及文献复习。结果 :DJS以慢性持续或间歇性黄疸为主要特征 ,血清胆红素一般轻度升高且以结合胆红素为主 ,ALT及AST正常 ;但并发病毒性肝炎或其它肝病时可升高。口服胆囊造影不显影 ;BSP试验呈典型双峰曲线 ,该方法已被淘汰。腹腔镜下肝脏呈特征性“黑肝”改变 ;肝活检细胞内有棕色或棕黄色色素颗粒沉着。结论 :腹腔镜检查和 /或肝活检是DJS诊断和鉴别诊断的重要方法。
Objective: To investigate the methods of diagnosis and differential diagnosis of Dubin Johnsonsyndrome (DJS). Methods: A retrospective analysis and literature review of 10 cases of DJS diagnosed in the Third Hospital of Beijing Medical University from 1996 to 1998 were conducted. Results: Chronic persistent or intermittent jaundice was the main characteristic of DJS. Serum bilirubin was generally mildly elevated and mainly bound to bilirubin. ALT and AST were normal; however, concurrent with viral hepatitis or other liver diseases, they could be elevated. Oral cholecystography does not develop; BSP test showed a typical bimodal curve, this method has been eliminated. Laparoscopic liver characteristic “black liver” changes; liver biopsy brown or brown pigment particles in the cell calm. Conclusion: Laparoscopy and / or liver biopsy are important methods for the diagnosis and differential diagnosis of DJS.