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目的 观察帕米膦酸二钠 (博宁 )配合局部放射治疗对骨转移癌性疼痛的止痛效果和副作用。方法 4 9例原发灶均经病理或细胞学证实 ,将博宁 90mg加入 5 %葡萄糖溶液 5 0 0ml中静脉滴注 ,每月 1次 ,共 3次。根据ECT及MRI检查结果 ,转移癌局部给予 6MV X线放射DT量 4 0 0 0CGY/ 2 0次 / 4周 ,以放疗结束后 3个月疼痛缓解率作为评定指标。结果 止痛总有效率 93 9% ,其中CR 5 1 0 % ,PR 4 2 9% ;起效时间 2～ 14d ,84 %在 1周内疼痛缓解。副作用有中 (低 )度发热、全身酸痛和轻度白细胞下降 ,经对症处理后均缓解。结论 博宁配合放疗可显著缓解骨转移癌引起的疼痛 ,减少并发症的发生。
Objective To observe the analgesic effects and side effects of pamidronate (Bonin) in combination with local radiotherapy on cancerous bone metastases. Methods Forty-nine cases of primary tumor were confirmed by pathology or cytology. Bonito 90mg was added to 5% dextrose solution in 500ml intravenously once a month for 3 times. According to the results of ECT and MRI, 6MV X-ray radiotherapy DT was given to the metastatic carcinoma at a dose of 400 Gy / 20 times / 4 weeks. The pain relief rate at 3 months after the end of radiotherapy was used as the evaluation index. Results The total effective rate of analgesia was 93 9%, of which CR 10% and PR 4 29%. The onset time was 2 ~ 14 days and 84% relieved pain within 1 week. Side effects of moderate (low) degree of fever, body aches and mild leukopenia, symptomatic treatment were relieved. Conclusion Boning with radiotherapy can significantly relieve the pain caused by bone metastases and reduce the incidence of complications.