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目的评价姜黄素联合小剂量MP方案化疗治疗老年多发性骨髓瘤的疗效及不良反应。方法治疗组25例采用姜黄素联合小剂量MP方案化疗,姜黄素自化疗开始时给药,剂量450mg/d,长期治疗。化疗方案采用小剂量MP方案(马法兰6mg/d,口服,第1～8d,泼尼松15mg/d,第1～8d),3周为1个疗程,连续治疗4～6个疗程。对照组25例,单纯应用小剂量MP方案化疗,方法及药物剂量均同治疗组。结果治疗组部分缓解21例,进展3例,无变化1例,总有效率84%,明显高于对照组(总有效率52%)(P<0.01)。治疗组疗效指标改善率优于对照组(P<0.01～P<0.05)。不良反应轻微且两组间无明显差异。结论姜黄素联合小剂量MP方案治疗老年多发性骨髓瘤具有不良反应小、耐受性好、疗效明显等优点,对老年多发性骨髓瘤患者不失为一个好的治疗方法,值得推广应用。
Objective To evaluate the efficacy and adverse reactions of curcumin combined with low-dose MP regimen in the treatment of elderly multiple myeloma. Methods 25 cases of treatment group with curcumin combined with low-dose MP regimen chemotherapy, curcumin administration since the beginning of chemotherapy, a dose of 450mg / d, long-term treatment. Chemotherapy program using a small dose of MP regimen (melphalan 6mg / d, orally, 1 ~ 8d, prednisone 15mg / d, 1 ~ 8d), 3 weeks for a course of treatment, continuous treatment of 4 to 6 courses. Control group of 25 cases, simple application of low-dose MP regimen chemotherapy, methods and drug doses were the same treatment group. Results In the treatment group, 21 cases were partially relieved and 3 cases were progress. There was no change in 1 case, the total effective rate was 84%, which was significantly higher than that in the control group (total effective rate was 52%) (P <0.01). The improvement rate of therapeutic index in treatment group was better than that in control group (P <0.01 ~ P <0.05). Minor adverse reactions and no significant difference between the two groups. Conclusion The combination of curcumin and low-dose MP regimen has the advantages of small adverse reactions, good tolerance and obvious curative effect in elderly multiple myeloma. It is a good treatment for elderly patients with multiple myeloma, which is worth popularizing and applying.