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目的探讨新诊断的T2DM患者高血糖状态纠正前后血清铁蛋白(SF)的变化。方法对120例新诊断的、FPG≥10mmol/L的T2DM患者行胰岛素强化治疗,观察高血糖状态纠正前后SF及多项临床资料,并与正常对照组资料进行比较。结果与对照组比:T2DM患者治疗前存在较高的C-RP、FPG、2hPG、HbA1c、SF、Fe、TS、Hb、RBC、MCV、MCH和MCHC,较低的C-P曲线下面积和P曲线下面积和TIBC,差异有统计学意义(P<0.05);治疗后与治疗前比:BMI、WHR、SBP、DBP、TC、TG、HDL-C、LDL-C、Fe、TS、Hb、RBC、MCV、MCH、MCHC和TIBC浓度差异无统计学意义(P>0.05),C-RP、SF明显降低,但仍高于对照组,C-P曲线下面积明显升高,但仍低于对照组,差异有统计学意义(P<0.01)。结论胰岛素强化治疗纠正高血糖状态能够使血清铁蛋白浓度降低。
Objective To investigate the changes of serum ferritin (SF) before and after correction of hyperglycemia in newly diagnosed T2DM patients. Methods 120 cases of newly diagnosed T2DM patients with FPG≥10mmol / L underwent insulin intensive therapy. SF and clinical data before and after hyperglycemia were observed and compared with those of the normal control group. Results Compared with the control group, T2DM patients had higher C-RP, FPG, 2hPG, HbA1c, SF, Fe, TS, Hb, RBC, MCV, MCH and MCHC before treatment. (P <0.05). After treatment, the ratio of BMI, WHR, SBP, DBP, TC, TG, HDL-C, LDL-C, Fe, TS, Hb, RBC (P> 0.05). There was no significant difference in the concentrations of C-RP, SF, MCV, MCH, MCHC and TIBC between the control group and the control group The difference was statistically significant (P <0.01). Conclusions Intensive insulin therapy to correct hyperglycemia can decrease serum ferritin concentration.