Na+-H+交换器是一类普遍存在于真核细胞膜上的离子交换蛋白,可介导胞外钠离子和胞内氢离子的交换,与肿瘤生长、代谢、血管新生以及多药耐药等密切相关,故有望成为抗肿瘤药物开发的新靶点。介绍了Na+-H+交换器基本原理及其抑制剂研究进展,旨在为抗肿瘤新药的开发拓宽思路并提供参考。 Na + -H + exchanger is a class of ion exchange proteins commonly found on eukaryotic membranes that mediate the exchange of extracellular sodium ions and intracellular hydrogen ions in close proximity to tumor growth, metabolism, angiogenesis, and multidrug resistance Related, it is expected to become a new target for the development of anti-cancer drugs. The basic principle of Na + -H + exchanger and the research progress of its inhibitors were introduced. The aim was to broaden the thinking and provide a reference for the development of new anti-tumor drugs.