我科从 1999年 3月～ 2 0 0 0年 5月加用妥泰治疗难治性癫 4 6例 ,现报道如下。资料与方法病例选择标准　①符合 1981年国际抗癫联盟癫发作分类中全身性发作及部分性发作的定义 ;②经一线抗癫药物系统正规治疗 1年以上仍频繁发作每月 4次以上 ;③影响正常工作、生活 ;? Our department from March 1999 ~ May 2000 plus topote refractory epilepsy treatment of 46 cases, are reported below. Materials and methods Case selection criteria ① in line with the 1981 International Antiepileptic Epilepsy Epilepsy seizures in the classification of generalized seizures and partial seizure definitions; ② first-line anti-epileptic drug system for more than 1 year of regular treatment is still frequent attacks 4 times a month Above; ③ affect the normal work, life;