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目的:探讨升麻乙酸乙酯可溶部对大鼠尿钙排泄和肾功能的影响。方法:实验组正常大鼠每天口服给予升麻乙酸乙酯可溶部(100mg/kg),对照组给予蒸溜水。每天收集大鼠排尿,观察摄食量,测定尿量、尿钙、尿肌酐,连续7天。结果:实验组大鼠与对照组在摄食量、总尿钙和尿肌酐排泄量上差异无统计学意义(P>0.05)。实验组大鼠排尿量增加(P<0.05)。结论:升麻乙酸乙酯可溶部对大鼠尿钙排泄和肾功能无影响,但具有一定的利尿作用。
Objective: To investigate the effect of ethyl acetate soluble fraction of cimicifugi on urinary calcium excretion and renal function in rats. Methods: The normal rats in the experimental group were orally administered with soluble fraction of ethyl acetate (100mg / kg) daily in the experimental group and distilled water in the control group. Rats were collected daily urination, observation of food intake, urine output, urinary calcium, urinary creatinine, continuous 7 days. Results: There was no significant difference in food intake, total urinary calcium and urinary creatinine excretion between the experimental group and the control group (P> 0.05). Rats in the experimental group increased urine output (P <0.05). Conclusion: The soluble fraction of ethyl acetate from Shengmai No effect on urinary calcium excretion and renal function in rats, but it has certain diuretic effect.