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目的通过临床对于肝纤维化的患者采用磁共振动态成像技术,评价该方法的临床应用价值。方法将本院2013年4月至2015年5月期间收治的45例经肝穿刺病理学检查诊断为肝纤维化的患者,按照疾病严重程度分为S1期组8例、S2期组12例、S3期组15例、S4期组10例,比较4组间肝实质的动态增强时间信号曲线(TIC)的峰高、信号下降最大斜率(MSD)、信号上升最大斜率(MSI)及达峰时间(TTP)的差异以及与纤维化程度的相关性。结果 4组间的信号上升及下降最大斜率、达峰时间、峰高均存在差异,且差异具有统计学意义(P<0.05),且TTP与肝纤维化程度呈正相关(P<0.05;r>0.453),峰高、MSD、MSI均与肝纤维化程度呈负相关(P<0.05;r<-0.396)。结论核磁共振动态增强成像技术对肝纤维化患者的血流动力学变化做出一定的判断,安全无创、方便快捷,是值得在临床上推广和使用的影像学检查方法。
Objective To evaluate the clinical value of this method by using magnetic resonance dynamic imaging in clinical patients with liver fibrosis. Methods 45 cases of liver fibrosis diagnosed by liver biopsy from April 2013 to May 2015 in our hospital were divided into 8 cases in S1 group and 12 cases in S2 group according to the severity of the disease. Fifteen patients in group S3 and 10 patients in group S4 were enrolled in this study. The peak heights, the maximum signal descending slope (MSD), the maximum signal slope (MSI) and peak time (TTP) and the correlation with the degree of fibrosis. Results There was a significant difference in peak rise, peak time and peak height between the four groups (P <0.05), and there was a positive correlation between TTP and liver fibrosis (P <0.05; r> 0.453), peak height, MSD and MSI were negatively correlated with the degree of liver fibrosis (P <0.05; r <-0.396). Conclusions The dynamic contrast-enhanced MR imaging technique can determine the hemodynamic changes in patients with liver fibrosis. It is safe, noninvasive and convenient. It is an imaging method worthy of promotion and use in clinic.