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目的研究氢氯吡格雷结合冠心舒通胶囊在经皮冠状动脉治疗介入(PCI)治疗急性冠脉综合征(ACS)术后对病人心绞痛的影响效果。方法将2014年—2017年在我院进行治疗的急性冠脉综合征病人80例纳入研究范围,在进行PCI术后,80例病人平均分成联合组和对照组。收集两组用药前后心绞痛发作频率和发作持续时间的数据;建立心绞痛评量标准,并进行记录数据;在用药前和用药后20d分别测量病人低密度脂蛋白胆固醇(LDL-C)和高敏C反应蛋白(hs-CRP)水平。结果在用药后心绞痛有效情况联合组占比95%,对照组占比仅为77.5%。结果表明,两种用药方式均能缓解术后心绞痛的发作频率和持续时间,hs-CRP和LDL-C在治疗后,联合组较对照组更趋于术前的稳定范围,数据比较具有统计学意义(P<0.05)。结论在PCI术后氢氯吡格雷结合冠心舒通胶囊能有效降低急性冠脉综合征病人血清中hs-CRP和LDL-C的含量,使心绞痛情况得到改善,控制心绞痛的持续时间和发作频次。
Objective To study the effect of clopidogrel in combination with Guanxin Shutong capsule on angina pectoris after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). Methods Eighty patients with acute coronary syndrome treated in our hospital from 2014 to 2017 were included in the study. After PCI, 80 patients were equally divided into the combined group and the control group. The data of angina pectoris frequency and duration of seizures were collected before and after treatment. Angina pectoris assessment standards were established and data were recorded. LDL-C and hypersensitivity C responses were measured before treatment and 20 d after treatment. Protein (hs-CRP) levels. Results The effective rate of angina in the combined group accounted for 95%, while the control group accounted for only 77.5%. The results showed that both treatment methods can ease the frequency and duration of postoperative angina pectoris, hs-CRP and LDL-C after treatment, the combined group compared with the control group tends to preoperative stability range, the data were statistically significant Significance (P <0.05). Conclusion Hydrochloride and clopidogrel in combination with Guanxin Shutong Capsule can effectively reduce the levels of hs-CRP and LDL-C in the serum of patients with acute coronary syndrome after PCI, improve the angina pectoris and control the duration and frequency of angina pectoris .