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目的:探讨甲状腺功能亢进(甲亢)孕妇经治疗后,其体内25-羟维生素D(25-(OH)D3)水平对42天婴儿胫骨声波的传导速度(speed of sound,SOS)值、骨代谢生化指标的影响。方法:选取我院门诊及住院确诊的甲亢孕妇40例为甲亢组(T组),随机抽取健康孕妇40例作为对照组(C组),甲亢组给予丙硫氧嘧啶治疗后,监测两组孕妇25-(OH)D3水平与生后42天婴儿的胫骨SOS值、骨代谢生化指标,并进行对比观察、统计分析。结果:甲亢组孕妇在产后42天体内25-(OH)D3的水平比其在产后第1天升高(P<0.05),甲亢组孕妇在产后42天体内25-(OH)D3水平接近对照组(P>0.05),在产后42天婴儿的胫骨SOS值接近对照组(P>0.05),甲亢组产后42天婴儿的血清钙(Ca)及血清碱性磷酸酶(AKP)接近对照组(P>0.05)。结论:甲亢组孕妇给予丙硫氧嘧啶治疗后,甲状腺功能恢复正常,其体内25-(OH)D3水平升高,所产42天婴儿的骨密度也随着升高。
Objective: To investigate the effects of 25-hydroxyvitamin D (25- (OH) D3) on the speed of sound (SOS) of 42-day infant tibial acoustic wave after the treatment of hyperthyroidism (Hyperthyroidism) The impact of biochemical indicators. Methods: Forty hyperthyroid patients (40 cases) with hyperthyroidism were selected as the control group (40 cases), and 40 healthy pregnant women were randomly selected as control group (C group). After treatment with propylthiouracil in hyperthyroidism group, pregnant women 25- (OH) D3 level and 42 days after birth, the tibia SOS value, biochemical markers of bone metabolism, and comparative observation, statistical analysis. Results: The level of 25- (OH) D3 in the hyperthyroidism group was higher than that on the first day postpartum (P <0.05), and the level of 25- (OH) D3 in the hyperthyroidism group was close to the control (P> 0.05). The SOS of tibia in infants at 42 days postpartum was close to that in control group (P> 0.05). Serum calcium and AKP in infants at 42 days postpartum were close to those in control group P> 0.05). CONCLUSION: Thyroid function returned to normal after hyperthyroidism treatment in pregnant women given propylthiouracil. The 25- (OH) D3 level in the hyperthyroidism group increased, and the BMD of the 42-day infant also increased.