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采用ＵＶ法测定７名哮喘患者单用氨茶碱和合用醋酸泼尼松后的稳态血清和唾液茶碱浓度。结果显示合用组与单用组茶碱的药动学参数分别为：Ｋ：０．１２８和０．０９９（Ｐ＜０．０１）；Ｔ＿（１／２）：６．３和８．６（Ｐ＜０．０５）；ＡＵＣ：５１．４０和７７．０１（Ｐ＜０．０５）；合用组Ｖ＿ｄ的ＳＤ较大（Ｐ＜０．００１）。泼尼松使唾液／血清浓度比值不稳定。提示泼尼松使茶碱代谢加快，分布改变。
The steady-state serum and salivary theophylline concentrations in seven asthmatic patients treated with aminophylline alone and in combination with prednisone acetate were determined by UV. The results showed that the pharmacokinetic parameters of the combination group and the monotherapy group were K: 0.128 and 0.099 (P <0.01); T 1/2: 6.3 and 8.6 ( P <0.05); AUC: 51.40 and 77.01 (P <0.05); SD of combination group V_d was larger (P <0.001). Prednisone made the ratio of saliva / serum concentration unstable. Prompts prednisone so that the metabolism of theophylline to speed up the distribution of changes.