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本文报告了通脉片对ADP诱导的家兔血小板聚集(试管法)及体外血栓形成具有显著的抑制作用。在一定范围内,药物作用强度随剂量的增加而增强。回归法计算了半数有效量(ED_(50))分别为18.98mg(生药)/ml(PRP)和62.55mg(生药/ml(血液)。实验结果还证明其抗聚及解聚作用优于当归注射液。
This article reports that Tongmai Tablets has a significant inhibitory effect on ADP-induced rabbit platelet aggregation (test tube method) and in vitro thrombosis. Within a certain range, the strength of the drug increases with increasing dose. The regression method calculated that the half effective amount (ED_(50)) was 18.98 mg (crude drug)/ml (PRP) and 62.55 mg (crude drug/ml (blood). The experimental results also proved that its anti-aggregation and depolymerization were superior to those of angelica. Injection.