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尽管有手术、放疗和化疗等综合治疗手段,在过去20多年,恶性脑胶质瘤特别是多形胶质母细胞瘤的预后并无明显改善。然而,在成人颅内恶性肿瘤中,多形胶质母细胞瘤每年的发病率占到50%以上[1]。虽然常规手术配合放化疗可以延长患者的生命,但是浸润性生长的特性决定了上述方法都无法有效清除肿瘤细胞,导致肿瘤在短时间内复发,患者的中位生存期一般不超过15个月[2]。免疫治疗通过激发和补
Despite the combined treatment of surgery, radiotherapy and chemotherapy, the prognosis of malignant gliomas, especially glioblastoma, has not improved significantly over the past 20 years. However, in adult intracranial malignancies, the incidence of glioblastoma accounts for more than 50% annually [1]. Although conventional surgery combined with radiotherapy and chemotherapy may prolong the life of patients, the characteristics of invasive growth determine that none of the above methods can effectively remove tumor cells and cause the tumor to recur within a short period of time, and the median survival time of patients is generally no more than 15 months [ 2]. Immunotherapy by excitation and make up