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多形性成胶质细胞瘤(Glioblastoma Multiforme,GBM)是成年人中最常见的原发性脑瘤,包括原发性和继发性GBM。GBM的遗传学的变异主要包括杂合性的丧失(Loss of heterozygosity,LOH)以及众多的基因突变和表达异常。其产生的机理与DNA修复的错误以及许多生长因子和癌基因信号通路有关。具有无限自我更新能力的胶质细胞瘤的干细胞(Gloima stem cells)可能来自停止发育的神经祖细胞或来自去分化的星形胶质细胞,是GBM复发的主要原因,有可能成为GBM治疗的新的靶点。
Glioblastoma Multiforme (GBM) is the most common primary brain tumor in adults, including primary and secondary GBM. The genetic variation of GBM mainly includes loss of heterozygosity (LOH) and a large number of gene mutations and abnormal expression. Its mechanism of production is related to the error of DNA repair and many growth factors and oncogene signaling pathways. Gloima stem cells of glioma with infinite self-renewal ability may come from cessation of development of neural progenitor cells or from dedifferentiated astrocytes, which is the main reason of GBM recurrence and may become a new treatment for GBM The target.