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目的探讨颅内出血患者血清IL-6、TNF-α的水平变化及在法医学的临床意义。方法采用酶联免疫吸附法(ELISA)对颅内出血患者住院后不同时间段血清IL-6、TNF-α水平进行检测,并与正常对照组的健康受试者进行比较分析。结果研究组重型与轻型患者后第1、3、5、7天血清IL-6、TNF-α水平较正常对照组明显增加,重型患者入院第5、7天的血清IL-6、TNF-α较轻型患者明显增加,差异有统计学意义(P<0.05);根据患者最后结果(死亡组和存活组),发现死亡组随着时间延长,在第5、7天时IL-6、TNF-α水平显著高于存活组(P<0.05)。此外,血清IL-6和TNF-α水平呈正性显著相关(r=0.721,P<0.05)。结论检测颅内出血患者血清IL-6、TNF-α水平对观察其病情变化有重要意义,可作为法医学鉴定的辅助手段。
Objective To investigate the changes of serum IL-6 and TNF-α in patients with intracranial hemorrhage and its clinical significance in forensic medicine. Methods Serum levels of IL-6 and TNF-α in patients with intracranial hemorrhage were detected by enzyme-linked immunosorbent assay (ELISA). The levels of TNF-α and IL-6 were measured and compared with those of healthy controls. Results Serum levels of IL-6 and TNF-α on the 1st, 3rd, 5th and 7th days in the study group were significantly higher than those in the normal control group. Serum levels of IL-6 and TNF-α (P <0.05). According to the final results of the patients (death group and survival group), the death group was found to be prolonged with time. On the 5th and 7th days, the levels of IL-6, TNF-α The level was significantly higher than the survival group (P <0.05). In addition, serum IL-6 and TNF-α levels were positively correlated (r = 0.721, P <0.05). Conclusion The detection of serum IL-6 and TNF-α levels in patients with intracranial hemorrhage is of great significance for the observation of the changes of the disease, and can be used as an auxiliary method for forensic identification.