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目的：研究苯那普利对４６例初发的未经任何处理的轻－中度原发性高血压患者的治疗效果，及对患者的血小板功能的影响。方法：采用临床观察分析其疗效，用比浊法和玻璃珠柱法分别测定血小板的聚集率与粘附率。结果：苯那普利有明显的降压作用（Ｐ＜０００１），第１周降压作用最大，第２周仍小幅度降低，对收缩压的影响较舒张压大。对心率的影响差异无显著意义（Ｐ＞００５）。血小板粘附率无明显降低（Ｐ＞００５），血小板１分钟聚集率明显降低（Ｐ＜０００５），５分钟和最大聚集率也明显降低（Ｐ＜０００１），治疗后与正常对照组无显著差异（Ｐ＞００５）。治疗前后经配对分析发现，治疗后血小板粘附率降低，而血小板聚集率有所升高，但均无显著性意义（Ｐ＞００５）。结论：初发的未经治疗的原发性高血压患者是处于低凝状态，苯那普利是一种有效安全的一线降压药物，但对于并有高凝状态者，应注意抗凝治疗。
OBJECTIVE: To investigate the effect of benazepril in the treatment of 46 patients with mild-to-moderate essential hypertension without any treatment and their effect on platelet function. Methods: Clinical curative effect was analyzed. Nephelometry and glass bead column method were used to determine the platelet aggregation rate and adhesion rate respectively. Results: Benazepril had a significant antihypertensive effect (P <0001). The antihypertensive effect was the highest in the first week, and decreased slightly in the second week, which had a greater effect on systolic blood pressure than diastolic blood pressure. There was no significant difference in heart rate (P> 005). Platelet adhesion rate was not significantly reduced (P> 0 05), 1 minute platelet aggregation was significantly reduced (P <0005), 5 minutes and the maximum aggregation rate was significantly lower (P <0001), after treatment with There was no significant difference between normal control group (P> 005). Paired analysis before and after treatment found that after treatment, platelet adhesion rate decreased, while the platelet aggregation rate increased, but no significant (P> 0 05). CONCLUSIONS: Initial untreated patients with essential hypertension are in a hypochromic state, and benazepril is a potent and safe first-line antihypertensive drug, but anticoagulant therapy should be considered in patients with hypercoagulable conditions .