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目的：探讨帕罗西汀对脑卒中后抑郁患者的临床疗效及神经功能康复的影响。方法将120例脑卒中后抑郁患者随机分为两组，每组60例，均予以脑卒中常规治疗及康复治疗，治疗组在此基础上联合帕罗西汀治疗，观察6周。于治疗前后采用汉密顿抑郁量表评定抑郁状况，脑卒中临床神经功能缺损程度评分量表评定神经功能康复状况。结果治疗后治疗组汉密顿抑郁量表及脑卒中临床神经功能缺损程度评分量表评分均较治疗前显著下降（P＜0．01），对照组仅汉密顿抑郁量表评分较治疗前显著下降（P＜0．01）；治疗6周末治疗组各量表评分均显著低于对照组（P＜0．01）。治疗组不良反应较轻微，随着治疗时间的延长可自行缓解或消失。结论帕罗西汀治疗脑卒中后抑郁效果显著，同时能促进患者神经功能的康复，且安全性高，依从性好。“,”Objective To explore the influences of paroxetine on clinical effect and nervous function reha-bilitation of patients with post-stroke depression (PSD) .Methods A total of 120 PSD patients were ran-domly divided into two groups of 60 ones each ,both groups received routine and rehabilitative treatment for stroke ,treatment group was plus paroxetine for 6 weeks .Depressive conditions were assessed with the Hamilton Depression Scale (HAMD) before and after treatment and nervous function rehabilitation with the Clinical Neurological Defect Scale (CNDS) .Results After treatment the HAMD and CNDS score low-ered more significantly in treatment compared with pretreatment (P<0 .01) ,so did the HAMD in control (P<0 .01);at the end of the 6th week each scale scores were significantly lower in treatment than control group (P<0 .01) .Adverse reactions in treatment were mild and could remit or disappeared spontaneously as the treatment time went on .Conclusion Paroxetine has an evident effect in the treatment of post-stroke depression and promotes nervous function rehabilitation simultaneously ,and has higher safety and better compliance .