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本研究旨在探讨北京市昌平区自然人群甲型肝炎(甲肝)病毒(HAV)血清学感染状况。采用多阶段整群随机抽样的方法抽取昌平区1岁以上自然人群538名,采集外周静脉血5ml,利用雅培微粒子酶免疫分析法检测抗-HAV IgG抗体。共检测538人,其中男性247人,女性291人,年龄1～91岁。城区276人,农村262人。HAV IgG抗体阳性率为86.43%(95%CI:83.54～89.32),标化阳性率为75.30%。男性HAV IgG抗体阳性率81.38%,女性阳性率90.72%,差异有统计学意义(χ2=9.949,P=0.002),随年龄增长,HAV抗体阳性率呈增长趋势(χ2=136.423,P=0.000),不同职业(χ2=75.442,P=0.000)及文化程度(χ2=10.961,P=0.004)间HAV抗体阳性率的差异有统计学意义,城乡间差异无统计学意义。研究显示,北京市昌平区自然人群甲肝感染率总体较高,14岁以下儿童为甲肝防控的重点人群。
This study aimed to investigate the serological status of hepatitis A (HAV) in natural population in Changping District of Beijing. A total of 538 natural subjects over the age of 1 in Changping District were collected by multi-stage cluster random sampling method. Peripheral venous blood was collected for 5 ml and anti-HAV IgG antibodies were detected by Abbott particle enzyme immunoassay. A total of 538 people were tested, including 247 males and 291 females, aged from 1 to 91 years old. 276 urban areas, 262 rural areas. The positive rate of HAV IgG was 86.43% (95% CI: 83.54 ~ 89.32). The positive rate of HAV IgG was 75.30%. The positive rate of HAV IgG in males was 81.38%, the positive rate in females was 90.72% (χ2 = 9.949, P = 0.002). With the increase of age, the positive rate of HAV antibodies showed an increasing trend (χ2 = 136.423, P = 0.000) There was significant difference in the positive rate of HAV antibody between different occupations (χ2 = 75.442, P = 0.000) and education (χ2 = 10.961, P = 0.004). There was no significant difference between urban and rural areas. Research shows that the prevalence of hepatitis A in Changping District of Beijing is generally high, and children under 14 years of age are the key people in prevention and control of hepatitis A.