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目的:探讨乙肝病毒前S1抗原在乙肝检测中的应用。方法:随机选取2013年1月--2014年1月来我院就诊的乙肝患者150例。采用ELASA和实时荧光定量,对乙肝病毒前S1抗原与HBV DNA的相关性、与HBV DNA、HBe Ag相关性进行分析。结果:乙肝病毒前S1抗原阳性检出率与HBV DNA具有高度的相关性;84.6%的HBV DNA阳性患者乙肝病毒前S1抗原成阳性,94.5%的HBe Ag阳性患者乙肝病毒前S1抗原成阳性。结论:乙肝病毒前S1抗原检测能够很好地反应乙肝患者体内HBV复制情况,可以作为乙肝检测的指标。
Objective: To investigate the application of hepatitis B virus pre-S1 antigen in hepatitis B detection. Methods: A total of 150 hepatitis B patients from January 2013 to January 2014 in our hospital were randomly selected. Using ELASA and real-time fluorescence quantitative analysis of the correlation between hepatitis B virus PreS1 antigen and HBV DNA, and HBV DNA, HBeAg. Results: The positive rate of pre-S1 antigen of HBV was highly correlated with HBV DNA; 84.6% of patients with positive HBV DNA were positive for HBV pre-S1 antigen and 94.5% of HBeAg-positive patients were positive for HBV pre-S1 antigen. Conclusion: The detection of hepatitis B virus pre-S1 antigen can well reflect the HBV replication in hepatitis B patients, which can be used as the index of HBV detection.