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以4～10Gy与5～20Gy分别照射大鼠与小鼠。照后第三天,动物的肝、脑、肾、心和骨髓细胞等组织脂类过氧化物(LPO)较未照射动物显著增高,而且随照射剂量增加而增加,但腹腔注射WR-2721可使5～20Gy照射后小鼠各组织LPO明显降低。8Gy与8.5Gy分别照射大鼠与小鼠,可使照后10天内,动物的肝、脑、肾、心、脾、睾丸、骨髓细胞等组织与肝的亚细胞器脂类过氧化率均有不同程度的增高,而且其时相性变各有差异。给予WR-2721可使照射小鼠的组织与细胞器中LPO水平显著降低。
Rats and mice were irradiated with 4 ~ 10Gy and 5 ~ 20Gy respectively. On the third day after irradiation, the lipid peroxidation (LPO) of liver, brain, kidney, heart and bone marrow cells of animals was significantly higher than that of non-irradiated animals and increased with the increase of irradiation dose. However, intraperitoneal injection of WR-2721 So that 5 ~ 20Gy mice LPO significantly reduced after irradiation. 8Gy and 8.5Gy irradiated rats and mice, respectively, so that 10 days after irradiation, animal liver, brain, kidney, heart, spleen, testis, bone marrow cells and other liver and liver tissue subcellular lipid peroxidation rates are different The degree of increase, but also the phase changes have different. Administration of WR-2721 resulted in a significant reduction of LPO levels in irradiated tissues and organelles.