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目的研究抵抗素和肥胖的关系,进一步探讨OSAHS可能的发病机制。方法以在我院呼吸科睡眠监测中心进行整夜7h多导睡眠图监测的94例就诊者为受试对象,监测其体重指数(BMI)、呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO2)、血氧饱和度低于90%时间百分比(SLT90%)、氧减指数(ODI)、空腹血糖(FPG)、三酰甘油(TG)等指标。根据AHI和BMI将受试者分为4组:OSAHS肥胖组(35例)、OSAHS非肥胖组(35例)、对照肥胖组(14例),对照非肥胖组(10例)。应用酶联免疫吸附法测定所有对象血清抵抗素水平。结果(1)OSAHS组血清抵抗素明显高于对照组。(2)OSAHS组FPG明显高于对照组。(3)OSAHS组TG水平高于对照组;(4)OSAHS组肥胖人群、OSAHS组非肥胖人群、对照组肥胖人群血清抵抗素水平与FPG具有正相关性。(5)OSAHS组肥胖人群、OSAHS组非肥胖人群、对照组肥胖人群血清抵抗素水平与TG具有正相关性。(6)OS-AHS组血清抵抗素水平与BMI具有正相关性。(7)OSAHS组人群血清抵抗素水平与LSaO2呈负相关。(8)OS-AHS组患者血清抵抗素水平与AHI呈正相关。(9)OSAHS组患者血清抵抗素水平与SLT90%呈正相关。(10)OSAHS组患者血清抵抗素水平与ODI呈正相关。结论测定血清抵抗素水平可望作为判断OSAHS病情严重程度的一项重要生物学指标,对于判断OSAHS患者病情严重程度具有重要的理论意义和应用价值,有利于及早采取措施预防OSAHS并发症的发生,降低其病死率。
Objective To study the relationship between resistin and obesity and to explore the possible pathogenesis of OSAHS. Methods A total of 94 patients who underwent polysomnography at 7h overnight in the Respiratory Sleep Monitoring Center of our hospital were enrolled in this study. Their body mass index (BMI), apnea hypopnea index (AHI), minimum oxygen saturation (LSaO2), oxygen saturation less than 90% of the time (SLT90%), oxygen reduction index (ODI), fasting blood glucose (FPG), triglyceride (TG) and other indicators. Subjects were divided into 4 groups according to AHI and BMI: OSAHS obesity group (35 cases), OSAHS non-obesity group (35 cases), control obesity group (14 cases) and control non-obese group (10 cases). Serum resistin levels were measured in all subjects by enzyme-linked immunosorbent assay. Results (1) Serum resistin in OSAHS group was significantly higher than that in control group. (2) The FPG in OSAHS group was significantly higher than that in control group. (3) The level of TG in OSAHS group was higher than that in control group. (4) The levels of serum resistin in obese OSAHS group, OSAHS group and control group were positively correlated with FPG. (5) The level of serum resistin in obese OSAHS group, non-obese OSAHS group and obese population in control group had a positive correlation with TG. (6) There was a positive correlation between serum resistin and BMI in OS-AHS group. (7) Serum resistin level in OSAHS group was negatively correlated with LSaO2. (8) Serum resistin levels in OS-AHS patients were positively correlated with AHI. (9) Serum resistin levels in OSAHS patients were positively correlated with SLT90%. (10) Serum resistin levels in patients with OSAHS were positively correlated with ODI. Conclusion The determination of serum resistin levels is expected to be an important biological index for judging the severity of OSAHS. It is of important theoretical significance and application value for judging the severity of OSAHS patients. It is beneficial to take early measures to prevent the occurrence of OSAHS complications, Reduce their mortality.