论文部分内容阅读
目的:观察清热化瘀方联合西药治疗缺血性中风的临床疗效。方法:将192例缺血性中风患者随机分为治疗组与对照组。治疗组予西医基础治疗+清热化瘀方颗粒剂;对照组给予基础治疗+吡拉西坦片,28 d为1个疗程。观察两组患者治疗前后的神经功能缺损积分(NIHSS)、运动功能积分(FMA)、生活质量积分(QLI)、中医证候积分和血清白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)含量的变化。结果:总有效率治疗组为94.4%,对照组为83.3%,治疗组优于对照组(P<0.05)。治疗后治疗组中医证候积分低于对照组(P<0.05)。两组患者治疗后NIHSS评分均较治疗前降低(P<0.05),FMA、QLI评分均较治疗前增加(P<0.05),且治疗组治疗后NIHSS评分低于对照组(P<0.05),FMA、QLI评分高于对照组(P<0.05)。两组患者治疗后血清IL-1β、TNF-α含量均降低(P<0.05),且治疗组治疗后血清IL-1β、TNF-α含量均低于对照组(P<0.05)。结论:清热化瘀方联合西药治疗缺血性中风患者疗效确切。
Objective: To observe the clinical efficacy of Qingre Huayu Recipe combined with western medicine in the treatment of ischemic stroke. Methods: 192 patients with ischemic stroke were randomly divided into treatment group and control group. The treatment group was given western medicine basic treatment + Qingre Huayu Fang granule; the control group was given basic treatment + piracetam tablets, 28 days for a course of treatment. Neurological deficit scores (NIHSS), motor function scores (FMA), quality of life scores (QLI), TCM syndromes scores and serum IL-1β (IL-1β) and tumor necrosis factor-α TNF-α) content changes. Results: The total effective rate was 94.4% in the treatment group and 83.3% in the control group, and the treatment group was superior to the control group (P <0.05). After treatment, the scores of TCM syndromes in the treatment group were lower than those in the control group (P <0.05). The scores of NIHSS in both groups after treatment were lower than those before treatment (P <0.05), while the scores of FMA and QLI in treatment group were higher than those before treatment (P <0.05), and the NIHSS scores in treatment group were lower than those in control group (P <0.05) FMA, QLI score higher than the control group (P <0.05). After treatment, the levels of IL-1β and TNF-α in the two groups were decreased (P <0.05), and the levels of IL-1β and TNF-α in the two groups were lower than those in the control group after treatment (P <0.05). Conclusion: Qingre Huayu Recipe combined with Western medicine in the treatment of ischemic stroke in patients with exact effect.