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1.Entropy and its implications in human disease and agingrnEntropy,which is a thermodynamic property or an interpreta-tion of the second law of thermodynamics,was first defined in 1865 by the German physicist Rudolph Clausius[1].It eventually evolved into
【机 构】
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Department of Pharmacology&State-Province Key Laboratories of Biomedicine-Pharmaceutics of China&Key
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1.Entropy and its implications in human disease and agingrnEntropy,which is a thermodynamic property or an interpreta-tion of the second law of thermodynamics,was first defined in 1865 by the German physicist Rudolph Clausius[1].It eventually evolved into a general scientific concept that is of universal and paramount importance in three aspects.First,entropy is a measur-able physical property that is commonly associated with a state of chaos,disorderliness,randomness,or uncertainty of any systems[2].Second,entropy is a measure of the amount of energy that is unavailable to do work[2].Third,the universe or an isolated sys-tem always obeys“the principle of entropy increase”that irre-versible or spontaneous processes can occur only in the direction of entropy increase-that is,the direction of increasing chaos,dis-order,randomness,or uncertainty[2].
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