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目的：报告5例小细胞膀胱癌治疗结果，复习相关文献，探讨小细胞膀胱癌临床特点，手术、化疗和放疗在小细胞膀胱癌治疗中的作用。方法：我院从1979~1999年收治5例小细胞膀胱癌患者，其中T1N0M0 1例，接受双髂内动脉导管化疗；T2N0M0 1例，行膀胱切除术加术后放疗；T3N0M0 1例，仅行膀胱切除术；T4N0M0 2例，1例经放疗、动脉导管化疗后行探查术，另1例术前放疗后行膀胱切除术加术后全身化疗。结果：T1T2患者无瘤生存8年，现正常生活；T3患者生存2年；T4患者分别生存6个月和4年。结论：小细胞膀胱癌的生存率与分期有关，最佳治疗方案是以顺铂为主的早期全身化疗及与手术或放疗结合的综合治疗。
OBJECTIVE: To report the results of 5 cases of small cell bladder cancer and to review relevant literature to investigate the clinical features of small cell bladder cancer, the role of surgery, chemotherapy and radiotherapy in the treatment of small cell bladder cancer. Methods: Five cases of small cell bladder cancer were treated in our hospital from 1979 to 1999. Among them, 1 case of T1N0M0 underwent bilateral internal iliac artery catheterization; 1 case of T2N0M0 underwent cystectomy plus postoperative radiotherapy; 1 case of T3N0M0, Cystectomy; T4N0M0 2 cases, 1 case after radiotherapy, patent ductus arteriosus underwent exploration, and the other 1 case underwent preoperative radiotherapy after cystectomy plus systemic chemotherapy. Results: T1T2 patients survived for 8 years without disease and lived in normal conditions. T3 patients survived 2 years and T4 patients survived 6 months and 4 years respectively. Conclusion: The survival rate of small cell bladder cancer is related to staging. The best treatment is cisplatin-based early systemic chemotherapy combined with surgery or radiotherapy.