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除虫菊酯越来越广泛地被应用于农业和家庭昆虫防治,主要通过作用于膜结合蛋白而对动物起神经毒性。迷迭香因其抗氧化功能而被应用于很多商业化的除虫菊酯产品中。本实验以大鼠大脑突触体ATP酶为研究对象,对除虫菊酯和迷迭香的药理学进行了研究.用Percoll梯度离心法分离突触体,通过检测无机磷的量来测定总ATP酶和Mg2+-ATP酶活性.结果表明,除虫菊酯在浓度为10μmol/L时总ATP酶和Mg2+-ATP酶分别降低到对照的80.3%和46.9%.迷迭香在浓度为0.3~30μmol/L时几乎不影响ATP酶活性,当浓度上升到3000μmol/L时,总ATP酶活性降低到66.8%,而Mg2+-ATP酶活性降低到54.5%.10μmol/L除虫菊酯和30μmol/L迷迭香混合物引起总ATP酶和Mg2+-ATP酶分别降低到72.9%和33.4%.结论:1)除虫菊酯能抑制大鼠大脑ATP酶活性;2)迷迭香只在高浓度下才对ATP酶有抑制作用;3)迷迭香能增强除虫菊酯对ATP酶的抑制作用.图3参19
Pyrethrins are increasingly used in agricultural and domestic insect control and are primarily neurotoxic to animals by acting on membrane-bound proteins. Rosemary is used in many commercial pyrethrin products for its antioxidant properties. In the present study, the pharmacology of pyrethrin and rosemary in rat brain synaptosomal ATPase was studied.The synaptosomes were isolated by Percoll gradient centrifugation and the total ATPase And Mg2 + -ATPase activity.The results showed that the total ATPase and Mg2 + -ATPase of pyrethrin decreased to 80.3% and 46.9% of the control respectively at the concentration of 10μmol / L. Rosemary at the concentration of 0.3 ~ 30μmol / L Almost did not affect the activity of ATPase, and the total ATPase activity decreased to 66.8% and the Mg2 + -ATPase activity decreased to 54.5% when the concentration increased to 3000μmol / L. The mixture of 10μmol / L pyrethrin and 30μmol / L rosemary caused Total ATPase and Mg2 + -ATPase decreased to 72.9% and 33.4% respectively.Conclusion: 1) Pyrethrins can inhibit ATPase activity in rat brain.2) Rosemary can inhibit ATPase only at high concentration; 3) Rosemary can enhance the inhibitory effect of pyrethrins on ATPase