某些研究人员对于麻风患者进行免疫治疗的报告,引起了人们很大的兴趣,但也有人认为这一新的疗法具有潜在的危险性。本文报告用可透析转移因子治疗3例瘤型及1例界线类麻风患者的过程中有关其毒性的初步资料。所用材料系取自医院工作人员麻风菌素试验阳性的健康人,并采用改良的Schulkind氏法制成。用对流电泳法来甄别供者是否存在肝炎相关抗原。在给病人治疗之前,先经5个步骤的操作过程进行Thioglyeollate培养,并将制剂进行灭菌。每次的注射用液,在冻干之前先以微孔滤器(孔大0.4微米)滤过;然后进行48小时及24小时的先后两次透析;在给病人进行皮下注射之 Some researchers’ reports of immunotherapy for patients with leprosy have aroused great interest, but others have suggested that this new therapy is potentially dangerous. This article reports preliminary data on the toxicity of dialysis-transporting agents in the treatment of 3 patients with neoplasia and 1 patient with borderline leprosy. The materials used were taken from hospitalized staff who were positive for the zeocin test and were made using a modified Schulkind’s method. Concurrent electrophoresis was used to screen donors for the presence of hepatitis-associated antigens. Thioglyeollate cultures were performed in a 5-step procedure prior to patient treatment and the formulations were sterilized. Each injection fluid was filtered through a micropore filter (0.4 μm pore size) before lyophilization; then, dialysis was performed twice successively for 48 hours and 24 hours; subcutaneous injections were given to the patient.