目的观察早期食管癌患者应用内镜下多环黏膜切除术(multi-band mucosectomy,MBM)的治疗效果及安全性。方法早期食管癌患者68例,依据内镜下手术方法不同分为行MBM者35例(MBM组)与行内镜黏膜剥离术(endoscopic submucosal dissection,ESD)者33例(ESD组),比较2组病灶完整切除率、手术时间及并发症等。结果MBM组手术时间((31.3±4.0)min)低于ESD组((47.2±4.6)min)(t=-15.195,P=0.000),2组病灶治愈性切除率和并发症发生率比较差异无统计学意义(P>0.05);术后随访3~24个月,2组均无病灶局部复发。结论早期食管癌患者应用MBM安全、有效,并发症少。 Objective To observe the therapeutic effect and safety of endoscopic multi-ring mucosectomy (MBM) in patients with early esophageal cancer. Methods Sixty-eight patients with early esophageal cancer were divided into two groups according to the method of endoscopic surgery: 35 cases (MBM group) and 33 cases (ESD group) with endoscopic submucosal dissection (ESD) Complete resection group lesions, operation time and complications. Results The operative time (31.3 ± 4.0) min in MBM group was significantly lower than that in ESD group (47.2 ± 4.6) min (t = -15.195, P = 0.000). There was significant difference between the two groups in the rate of curative resection and complication No statistical significance (P> 0.05); 3 months to 24 months follow-up, no local recurrence of the two groups. Conclusion The application of MBM in patients with early esophageal cancer is safe, effective and has fewer complications.