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目的观察中西药联合治疗围绝经期功能失调性子宫出血(功血)的临床价值。方法将围绝经期功血患者82例随机分中西药联合组及单纯西药组各41例,单纯西药组应用妈富隆治疗,月经周期第1天起1片,连服21 d,7 d后再开始新周期治疗,连续应用3个月经周期;中西药联合组应用妈富隆治疗的同时加中药治疗,每天1剂,连服7 d,下次月经周期又有非正常子宫出血者,按前法服用,3个疗程结束后观察2组Hb水平及子宫内膜厚度,比较2临床疗效。结果 2组患者治疗前Hb及子宫内膜厚度比较无显著性差异(P>0.05)。治疗后2组患者Hb水平高于治疗前,子宫内膜厚度小于治疗前,且中西药联合组患者的Hb水平及子宫内膜厚度变化幅度均大于单纯西药组,差异均有统计学意义(P<0.05)。治疗后中西药联合组患者的总有效率为91.12%明显高于对照组患者82.93%,差异有统计学意义(χ2=4.32,P<0.05)。结论中西结合治疗围绝经期功血可明显提高血红蛋白水平,改善子宫内膜增生,疗效显著。
Objective To observe the clinical value of combined traditional Chinese and western medicine in treating peri-menopausal dysfunctional uterine bleeding (dysfunctional uterine bleeding). Methods 82 cases of peri-menopausal dysfunctional uterine bleeding were randomly divided into two groups (n = 41 in each group) and western medicine group (n = 41). The western medicine group was treated with marvelon once a day on the first day of the menstrual cycle, The beginning of the new cycle of treatment, continuous application of three menstrual cycles; Chinese and Western medicine combined with Marvelon treatment plus Chinese medicine treatment, day 1, and even served 7 d, the next menstrual cycle and abnormal uterine bleeding, according to the former method After taking the three courses of treatment, the levels of Hb and endometrial thickness were observed in two groups, and the clinical effects were compared. Results There was no significant difference in Hb and endometrial thickness between the two groups before treatment (P> 0.05). Hb levels in two groups after treatment were higher than those before treatment, endometrial thickness was less than before treatment, and Hb level and endometrial thickness in both groups were significantly higher than those in western medicine alone group (P <0.05). After treatment, the total effective rate of the combined Chinese and western medicine group was 91.12%, which was significantly higher than that of the control group (82.93%), the difference was statistically significant (χ2 = 4.32, P <0.05). Conclusion Chinese and Western treatment of peri-menopausal dysfunctional uterine bleeding can significantly improve hemoglobin levels, improve endometrial hyperplasia, the effect is significant.